wilkins hm, harris jl, carl sm, et al. oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. hum mol genet. 2014;23(24):6528-6541.

Answers

Answer 1

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation, and stimulates neurogenesis, as observed in a study by Wilkins et al. (2014).

The study conducted by Wilkins et al. in 2014 demonstrated that oxaloacetate, a compound involved in energy metabolism, has several beneficial effects on the brain. Oxaloacetate was found to activate the process of mitochondrial biogenesis, which is responsible for the production of new mitochondria, the cell's powerhouses. Additionally, it enhanced the insulin pathway, which plays a crucial role in regulating glucose metabolism in the brain. The compound also exhibited anti-inflammatory properties, reducing inflammation in the brain. Moreover, oxaloacetate stimulated neurogenesis, the formation of new neurons, potentially promoting brain health and function. These findings suggest that oxaloacetate may have therapeutic potential for various neurological conditions.

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Related Questions

A ___ is used to examine the eyelids, iris, lens, and cornea, and consists of a magnifying lens combined with a light source.

Answers

Answer:

A slit lamp is used to examine these parts

why is a magnitude scale called a backward scale?

Answers

Answer:

It is called the ‘backwards scale’ as the magnitude goes backwards, and because ancient astronomers had flaws in the scale, including the ‘backwards’ aspect.

Explanation:

Hope I helped!

need rn!!!!!
What macromolecules make up the cell membrane? Based on the information you have from the diagram. (check all that apply)
- polysaccharides
- proteins
- lipids
- nucleic acids

need rn!!!!!What macromolecules make up the cell membrane? Based on the information you have from the

Answers

Answer:

Proteins and lipids

Characteristics of Living Things: (List each of the characteristics of life and tell why they are important) There is not a set number of steps so when you look them up you may find 6, 8, or 8 steps.​

Answers

Answer:

Reproduction: ensures the continuity of various species on the Earth

Homeostasis: maintains optimal conditions for enzyme action throughout the body, as well as all cell functions

Growth: Growth is a way to generate the materials for reproduction.

Respiration: It releases energy from the food

Excretion:to prevent accumulation of harmful substances in the body.

Nutrition: help break down food to give organisms energy

Explanation:

hope this helps

c or d is the correct answer​

c or d is the correct answer

Answers

\({ \red{ \sf{C.}}}\)

I thinks so that the answer is Blood blow backwards.

Answer:

D

Explanation:

Un instructor desea preparar un experimento sobre movimiento armónico simple. Sólo dispone de una masa de 2 kg pero tiene una colección de resortes. ¿Qué constante elástica, en N/m, debe elegir para tener un período de 2 s?

Answers

Answer:

Constante de resorte, k = 19.745 N/m

Explanation:

Dados los siguientes datos;

Masa, m = 2 kg

Periodo, T = 2 segundos

Para encontrar la constante del resorte, k;

\( Period, \; T = 2 \pi \sqrt {\frac {m}{k}} \)

Dónde;

T es el período. m es la masa del objeto. k es la constante del resorte.

Haciendo k el tema de la fórmula, tenemos;

\( k = \frac {(2 \pi )^{2}m}{T^{2}} \)

Sustituyendo en la fórmula, tenemos;

\( k = \frac {(2 * 3.142)^{2} * 2}{2^{2}} \)

\( k = \frac {6.284^{2} * 2}{4} \)

\( k = \frac {39.49 * 2}{4} \)

\( k = \frac {78.98}{4} \)

Constante de resorte, k = 19.745 N/m

 For each phenotype, write the possible genotypes.

In dogs, deafness is recessive.

Deafness: ____________________

Normal hearing: ______,____

Answers

We are gonna call the recessive gene of deafness d and normal hearing D.

Deafness: dd

Normal Hearing: DD, Dd

In order for deafness to occur there must be two genes because so long as there is the dominate gene of D present it will always be normal hearing.

the personality of an individual involves his or her​

Answers

Answer:

both

Explanation:

depends on the person's personality I guess or how they act n all

Which of the following is true of clouds at medium altitudes?
A. They are a sign of severe weather.
B. They generally produce lightning.
C. They cause light rain and snow.
D. They are made of ice crystals.

Answers

Answer:

D

Explanation:

they are made of ice crystals

Answer:c

Explanation:

sorry if its wrong

A frame which is used for ecological sampling

Answers

Answer:

A quadrat is a frame (usually a square or a circle) of known area used to isolate a subset of the population. This subset will comprise one sample. Quadrats come in various sizes (and shapes) with the size selected determined by features of the organisms in the population to be sampled.

Explanation:

hope this helps

C4 plants differ from c3 and cam plants in that c4 plants____.

Answers

Answer:

The difference between C3, C4, and CAM photosynthesis is the way plants extract carbon dioxide from sunlight. This depends largely on the plant's habitat. C3 photosynthesis produces three-carbon compound via the Calvin cycle while C4 photosynthesis makes an intermediate four-carbon compound that splits into a three-carbon compound for the Calvin cycle. Plants that use CAM photosynthesis gather sunlight during the day and fix carbon dioxide molecules at night.

CAM plants open their stomata at night, C3, and C4 open during the day.

Explanation:

Answer: Transfer Fixed carbon dioxide to cells in which the Calvin Cycle occurs.

"Overall, how well do you believe the Bearington plant case and Theory of Constraints (TOC) in general align with the habits of highly effective people? (Describe and support your
conclusion).

Answers

The Bearington plant case and the Theory of Constraints (TOC) align well with the habits of highly effective people.

Firstly, TOC emphasizes the habit of prioritizing and focusing on the most critical aspects of a system or process. In the Bearington plant case, the TOC approach identified the bottleneck operation and focused efforts on improving its efficiency. This aligns with the habit of highly effective people who prioritize their tasks based on their importance and impact.

Secondly, TOC encourages continuous improvement and problem-solving. The case study demonstrates this through the implementation of various improvement initiatives to address the bottleneck and optimize the entire system's performance. This aligns with the habit of highly effective people who constantly seek ways to enhance their processes and overcome obstacles.

Furthermore, TOC promotes a systems-thinking mindset, which is also essential for highly effective individuals. It encourages considering the entire system rather than optimizing individual components in isolation. In the Bearington plant case, the TOC approach aimed to improve the overall throughput of the plant, taking into account the interdependencies between different operations. This aligns with the habit of highly effective people who understand the interconnectedness of various factors and make decisions that consider the bigger picture.

In conclusion, the Bearington plant case and TOC align well with the habits of highly effective people. The focus on prioritization, continuous improvement, and systems thinking reflects the principles that highly effective individuals adopt in their personal and professional lives.

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Discuss the function of hemoglobin in human body and the consequences of hemoglobin
deficiency

Answers

Hemoglobin: The high iron-containing protein in red blood cells (RBCs) is known as hemoglobin. This gives the blood a red color.

It has two main functions: it carries oxygen from the lungs to tissues of the body, and it carries carbon dioxide from cells back to the lungs for excretion.

Functions of hemoglobin:

Hemoglobin is the main reason for the red color in our blood.Hemoglobin carries oxygen and carbon dioxide. Hemoglobin interacts with other ligands.Hemoglobin plays a crucial role in maintaining the shape of red blood cells.

Consequences of hemoglobin deficiency:

Hemoglobin deficiency leads to having fewer red blood cells and causes anemia.It is found in red blood cells and acts as a carrier of oxygen and carbon dioxide.Low levels of hemoglobin in the blood cause parts of the body to function more slowly and weaken due to reduced oxygenation.

Hemoglobin deficiency reduces the blood's oxygen-carrying capacity.

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All organisms need a place to live that provides? I

Answers

Answer:

food shelter water

Explanation:

food shelter water

Writing to Learn Imagine: that you are a student in the 1860s visiting Gregor Mendel in his garden. Write a letter to a friend describing Mendel's experiments with pea plants

Answers

A letter to a friend describing Mendel's experiments with pea plants may be based on how different generations have statistically uniform traits in regard to the parental generation.

What is the relative importance of Mendel's experiments?

The relative importance of Mendel's experiments was based on the fact he observed traits or characters segregated in different generations of pea plants, which led him to develop a series of laws for inheritance.

Therefore, with this data, we can see that the relative importance of Mendel's experiments is cemented by the observation of statistically uniform inheritance laws.

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Which of the following is an important distinction between the measurement of basal metabolic rate (BMR) and standard metabolic rate (SMR)?
A) An animal must be fasting for the measurement of SMR.
B) BMRs are performed only on ectothermic animals.
C) An organism must be actively exercising for the measurement of BMR.
D) SMRs must be determined at a specific temperature.
E) The BMR for a particular animal is usually lower than that animal's SMR.

Answers

A) An animal must be fasting for the measurement of SMR. Option A is the correct distinction between the measurement of basal metabolic rate (BMR) and standard metabolic rate (SMR).

BMR refers to the metabolic  rate of an animal at rest under thermoneutral conditions, whereas SMR refers to the metabolic rate of an ectothermic animal (such as a fish or reptile) at rest under specific standard conditions, which typically include fasting for a specific period of time.

In contrast to BMR, which is typically measured in endothermic animals (such as mammals and birds) and does not require fasting, SMR measurements usually require the animal to be fasted to obtain a true resting metabolic rate. This is because in ectothermic animals, the metabolic rate can be greatly influenced by recent feeding activity and digestion, so fasting is necessary to obtain a more accurate measurement of the animal's true resting metabolic rate.

Option B is incorrect because BMR measurements can also be performed on endothermic animals, not just ectothermic animals.

Option C is incorrect because BMR measurements are typically obtained when the animal is at rest, not actively exercising.

Option D is incorrect because BMR is typically measured under thermoneutral conditions, where the animal does not need to be exposed to a specific temperature.

Option E is incorrect because BMR and SMR are used interchangeably in many contexts, and there is no general rule that BMR is always lower than SMR. The relative values of BMR and SMR can vary depending on the species, environmental conditions, and other factors.

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Describe the three parts of a bone?​

Answers

Bones actually have four main parts not three: the diaphysis, the distal epiphysis, the proximal epiphysis and the metaphysis.

Which statement best distinguishes between genes and chromosomes?
Genes carry all of an organism's genetic information, while chromosomes only carry the genetic information needed for
reproduction.
O Genes are mutated segments of DNA, while chromosomes are protected from mutations.
O Genes are segments of DNA, while chromosomes are made of many genes strung together.
O Genes are long loops of DNA, while chromosomes are short segments of DNA.
O Genes are long loops of DNA, while chromosomes are short segments of DNA.

Answers

The statement which best distinguishes between genes and chromosomes is that Genes are segments of DNA, while chromosomes are made of many genes strung together. Thus, the correct option for this question is C.

What are Chromosomes?

Chromosomes may be defined as thin, thread-like structures that may appear in the nucleus of the cell during the process of cell division. These structures may contain DNA, RNA, histones, and non-histone proteins. Chromosomes may be discovered by E. Strasburger in 1875.

While genes are made up of sequences of DNA and are arranged, one after another, at specific locations on chromosomes in the nucleus of cells. It is the basic unit of heredity passed from parent to child.

Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body. Chromosomes are structures within cells that contain a person's genes.

Therefore, the correct option for this question is C.

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acquiring an r plasmid would allow a bacterium to do what?

Answers

Acquiring an R-plasmid would allow a bacterium to develop antibiotic resistance, survive in harsh conditions, spread antibiotic resistance and increase virulence.

The acquisition of an R-plasmid would enable a bacterium to do the following:

1. Develop antibiotic resistance: R-plasmids carry genes that encode resistance to one or more antibiotics. This implies that if a bacterium obtains an R-plasmid, it will be able to resist the effects of antibiotics that would ordinarily kill or inhibit its growth.

2. Survive in harsh conditions: Some R-plasmids bear genes that enable bacteria to sustain in extreme environments, such as those with high levels of radiation, heavy metals, or other toxic substances.

3. Spread antibiotic resistance: Bacteria can transfer R-plasmids between themselves through horizontal gene transfer. This indicates that a bacterium with an R-plasmid can spread antibiotic resistance to other bacteria in the same environment.

4. Increase virulence: Some R-plasmids carry genes that increment the virulence (ability to cause disease) of bacteria. This suggests that a bacterium with an R-plasmid may be more likely to instigate serious infections in humans or animals.

Therefore, the acquisition of an R-plasmid would provide a bacterium with a significant advantage in terms of its ability to survive in harsh environments, resist antibiotics, spread antibiotic resistance, and potentially trigger more severe infections.

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tissue culture method of an artificial vegetative propagation in plants play a great role in Forestry Horti culture and agriculture field clarify this statement in three point​

Answers

Please give brainliest to support:

here are three points that clarify the statement that tissue culture method of artificial vegetative propagation plays a great role in forestry, horticulture, and agriculture:

Mass Production of Clones: Tissue culture allows for the production of large numbers of identical clones of plants. This is particularly useful in forestry, where certain desirable traits such as disease resistance or fast growth can be propagated on a large scale. Similarly, in horticulture and agriculture, tissue culture is used to mass-produce desirable varieties of plants, such as fruit trees or ornamental plants, which can then be sold to consumers.
Disease-Free Plants: Tissue culture is a sterile process that allows for the production of disease-free plants. This is particularly important in agriculture and horticulture, where plant diseases can cause significant economic losses. Tissue culture allows for the production of healthy plants, which can then be used to establish disease-free plantations or gardens.
Genetic Modification: Tissue culture can also be used for genetic modification of plants. This is particularly important in agriculture, where genetically modified plants can be developed to be resistant to pests or to produce higher yields. Tissue culture allows for the precise manipulation of plant cells and genes, leading to the development of new plant varieties that have desirable traits.

Fears of malpractice lawsuits are playing a part in the increased use of expensive diagnostic equipment. T F

Answers

Answer:

True.

Explanation:

True, Fears of malpractice lawsuits are playing a part in the increased use of expensive diagnostic equipment.

Hope this helps!

COLLABORATE Brainstorm several human activities common in urban areas, with your partner. Rank these activities from the most to the least sustainable.

please help

Answers

Sustainable human activities promote the environment while non-sustainable human activities degrade the environment.

What are some human activities in urban areas?

Human activities refers to the various activities carried out by humans in their day to day to help them survive or adapt to their envrionment.

Human activities may either be sustainable or non-sustainable to then and the environment

Some human activities common in urban areas include:

agriculture music and dance sports and gamesdriving of vehicles

The most sustainable of these activities is agriculture while the least sustainable is driving of vehicles.

Therefore, sustainable human activities promote the environment while non-sustainable activities degrade the environment.

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Will mark Brainlest

Will mark Brainlest

Answers

Answer:

Uh~ Give the other guy brainlest. Also this was a project for you, a Hypothesis. There are no right or wrong answers with a Hypothesis. :0

Explanation:

through _____ large molecules are formed

Answers

Answer:
Biological macromolecules
Hope this helps!

Answer:

Macromolecules

Explanation:

because they combine with covalent bonds

Your colleague has collected some sediments from a mangrove swamp and then grows the bacteria from those sediments on an agar plate to determine the concentration of bacteria in those sediments.

a) Describe why the resulting bacterial concentration is an underestimate of the actual concentration of bacteria in those sediments.

b) State what method they should have used instead to more accurately determine the bacterial concentration.

Answers

From the question;

1) It may have been underestimated sue to visibility bias

2)  The method of direct microscopic count or direct cell count can be employed.

What about the bacteria?

On the particular agar medium employed, not all bacteria contained in the sediments may be viable or able to grow. Some bacteria might no longer be culturable or in a dormant state, which limits their capacity to grow into colonies on the agar plate. This viability bias may lead to the underestimate of the bacterial population by excluding a sizable fraction of it.

A direct microscopic count entails using a microscope to directly observe and count bacterial cells. Without the bias imposed by culture-based approaches, it provides a more thorough count of bacterial cells, including viable and non-viable cells.

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During Drosophila development, there is a regulatory cascade of gene activation. The proper sequence for this cascade is _____.

Answers

During Drosophila development, the proper sequence for the regulatory cascade of gene activation is: maternal effect genes, gap genes, pair-rule genes, and segment polarity genes.

This cascade ensures the correct development and differentiation of various body segments in the organism.

The first step in this regulatory cascade involves the activation of maternal effect genes, which are expressed in the oocyte and early embryo. These genes provide the initial spatial cues that establish the anterior-posterior and dorsal-ventral axes of the embryo.

The maternal effect genes encode proteins and RNA molecules that are stored in the egg and later distributed throughout the developing embryo.

Next, the gap genes are activated in broad regions of the embryo, dividing it into distinct regions or "gaps." These genes are expressed in response to the spatial cues provided by the maternal effect genes.

Gap genes encode transcription factors that control the expression of downstream genes and help define the boundaries of the developing segments.

After the establishment of the broad regional pattern of gene expression by the gap genes, the pair-rule genes are activated in alternating segments. These genes help to refine the segmental pattern and further define the boundaries of the developing segments.

Pair-rule genes are expressed in response to the spatial cues provided by the gap genes.

Finally, the segment polarity genes are activated in each segment, which are responsible for the formation of the anterior-posterior polarity within each segment. These genes control the expression of downstream genes that determine the identities of the different cell types within each segment.

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which theory explains that physiological needs create an arround state that otivates an organism to redue the need

Answers

The theory that explains how physiological needs create a state of arousal that motivates an organism to reduce the need is called the Drive Reduction Theory

According to this theory, when an organism experiences a physiological need, such as hunger or thirst, it creates a state of tension or arousal. This tension motivates the organism to engage in behaviors that will satisfy the need and reduce the tension or arousal. Once the need has been satisfied and the tension has been reduced, the organism returns to a state of equilibrium until another need arises. Drive Reduction Theory is often used to explain basic human and animal motivations, such as hunger, thirst, and the need for warmth or sleep.This theory was first proposed by Clark Hull and his colleagues in the 1940s. According to the theory, physiological needs create a state of arousal that motivates an organism to engage in behaviors that will reduce the need and return the organism to a state of equilibrium. The theory suggests that the strength of the drive is proportional to the magnitude of the need, meaning that the stronger the need, the greater the drive to satisfy it.

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37) Most of Oxygen resource is from
photosynthesis that happen
in ..........
A.
rainforests
B.
soil
C.
ocean
D.
river and lakes

Answers

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Scientists estimate that 50-80% of the oxygen production on Earth comes from the ocean.

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37) most of oxygen resource is from photosynthesis that happens in..?

A. Rainforests
B. Soil
C. Ocean
D. Rivers and lakes

Answer: letter C

experimental archaeology provides archaeologists with bridging arguments, ways to make inferences about past behavior from material remains. which of the following is not an example of experimental archaeology? A. Using a stone tool to scrape hide and then examining microwear present on tool's edge to determine the type of wear caused by hide scraping. B. Using British schoolboys to see if they could move stones similar to those used to build Stonehenge. C. Throwing hafted spear points into elephant carcasses to determine their capacity for penetration. D. Using seriation to construct a way to date archaeological sites based on painted pottery styles.

Answers

Experimental archaeology provides archaeologists with bridging arguments, and ways to make inferences about past behavior from material remains. D. Using seriation to construct a way to date archaeological sites based on painted pottery styles is not  an example of experimental archaeology

Experimental Archaeology is an approach for filling gaps in our information about the past, which cannot be filled through other archeological research strategies. An archeological experiment must continuously reply to a particular investigative address through for all intents and purposes testing production, utilization, and/or formation of fabric culture and/or archeological highlights. In Exploratory Archaeology, testing speculation in coordinate reference to the archeological record is the central action. The data gained ought to be incomprehensible to get from exclusively analyzing unique antiques. The hone of exploratory paleontology is emphatically associated with the other four legs of EXARC as developing make the encounter, as well as an elucidation, can too lead to inquiries about questions and experimental ventures.

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What ecological service do the wetland provide?

Answers

Answer:

They improve water quality, prevent soil erosion and land mass loss, protect coastlines, store away carbon, and provide habitats for a wide range of diverse plant and animal communities.

Explanation:

Wetlands are regions or areas of or periodically water-covered soil. These are classified as swamps, marshes, bogs, fens and shallow water. Others, that contain partially decomposed organic matter are known as peatlands.

These are diverse and essential regions found across several biospheres. They improve water quality, prevent soil erosion and land mass loss, protect coastlines, store away carbon, and provide habitats for a wide range of diverse plant and animal communities. Additionally, wetlands remove excess nutrients from runoff, preventing pollution of waterways.

Answer:

They improve water quality, prevent soil erosion and land mass loss, protect coastlines, store away carbon, and provide habitats for a wide range of diverse plant and animal communities.

Explanation:

look up

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According to the reading, which planning tool is largely responsible for land segregation in cities? Evolution doesn't work according to any plan or change in any particular direction. Sometimes it leads to the rise of more complex organisms, but usually it leads nowhere and an organism dies out. We call a species that dies out extinct. Most of the organisms that have evolved in the past are now extinct. Extinctions take place when the environment changes and one or more species cannot adapt. Sometimes the environment changes because a better-suited organism arrives to compete. Sometimes climates change. Parts of North Africa, now covered in desert, were once home to rivers, lakes and plants. Parts of Antarctica now buried in ice once grew tropical plants. Evidence suggests that giant meteors have crashed into the Earth at various times in history, causing mass extinctions. It is believed that such a crash 70 million years ago made the dinosaurs extinct. Which of the following is a false statement? A Some deserts we know today once had rivers and lakes. B Mass extinctions may have been caused by meteors. C Very few species have ever gone extinct. D Sometimes, species evolve to be more complex. these form a proportion: 10 altos for every 16 sopranos, 5 altos for every 8 sopranos. True or False? What do peritonitis, pleurisy and pericarditis all have in common? In your explanation include the meaning of each term and list all the membranes involved Answer completely! 8pts. Why is pain involved? 3 pts What will a 68% do to a 72.99%? Help me with these two questions please !!!!!!!!!!!!!! What is the process of tracking multiple versions of a file?is the process of tracking multiple versions of a file. Which process will increase variations that could be inherited? (1) mitotic cell division (2) active transport (3) recombination of genes (4) synthesis of proteins .837537537 as a fraction List some discussion questions or reflections related to code-switching or to themes in the Gwendolyn Brooks's poem. Write a paragraph suggesting your own answer to one of these questions. you are running the ir to see of the final product contains magnesium. you are running the ir to see of the final product contains magnesium. true or false a random sample of size 24 from a normal distribution has standard deviation s=62 . test h0:o=36 versus h1:o/=36 . use the a=0.10 level of significance. Helpppppp Ill mark brainliest What is the answer for this one? Please help me with this thank you Disease that is characterized as having lack of energy and protein is called? The average revenue for Professional Road Bikes in the US market was $17,362, and in Germany was $19,669. Can you conclude that road bike sales in Germany are significantly higher than in the US? Yes, or no? why? Explain your answer in a few sentences. the textbook defines gender discrimination as something that: group of answer choices involves the denial of a job. only affects women. is very uncommon. is found only in ethnic minority populations. Benny bought 4 new baseball trading cards to add to his collection. The next day his dog ate half of hiscollection. There are now only 24 cards left.How many cards did Benny start with? Which sentence is the thesis statement school uniforms Anne said to Betty: "If you give me one marble, we will each have the same number of marbles." Betty said to Anne: "If you give me one marble, I will have twice as many marbles as you will then have."How many marbles did Anne have before any exchange was made?